NEWS—

Requirements of 5 major industries for clean room environment


In recent years, with the development of modern science and technology and the deepening of a new round of industrial revolution, developed countries have implemented re-industrialization strategies. Digitalization and intelligent technology have profoundly changed the production mode and industrial form of the manufacturing industry. Coupled with major breakthroughs in new materials and new energy technologies, it will trigger a new round of technological and industrial changes.
Especially in the processing and production of high-tech products, how to meet the requirements of precision processing, product miniaturization, high purity (high quality), high reliability, etc. High demands. On the other hand, with the development of modern biomedicine, the requirements for the control of the number of bacteria in the clean room and the contamination of microorganisms are also increasing to ensure that industries such as medical and pharmaceutical, biological research, and food production will not be contaminated or infected by microorganisms.
  Industrial cleaning technology and biological cleaning technology will develop rapidly with the development of science and technology and the rapid development of industrial products, and become one of the indispensable important technical signs of modern industrial production and scientific experimental activities.
   At present, clean technology has been widely used in various industries or other environmental control requirements to prevent particle pollution and microbial pollution. Due to the wide gap between industries and the different requirements, the content and indicators of the control environment are different. The following is a summary of common industry clean technology requirements.
   1. Cleanroom requirements for the production of pharmaceutical products
  Pharmaceuticals are special commodities used for prevention, treatment of diseases, recovery and adjustment of body functions. Its quality is directly related to human health and safety. If some medicines are contaminated or cross-contaminated with microorganisms, dust particles, etc. during the manufacturing process, unexpected diseases and hazards may occur.
   2. Cleanroom requirements in medical applications and medical research
  Industrial environmental control represented by integrated circuits mostly uses industrial clean technology and industrial clean rooms; while in medicine, biological clean rooms are often used for microbial pollution control. In a biological clean room, these microorganisms are mostly composed of bacteria and fungi, with a particle size of more than 0.2um, common bacteria have a particle size of more than 0.5um, and most of them are attached to other particles. The biological pollution channel not only passes through the air, but also relates to the human body and the clothing of the operator.
  In the field of medical research, biological laboratories, aseptic laboratories, and "special breeding animals" breeding rooms for biochemistry and medical experiments are also in great need to control microbial contamination.
3. The clean room requirements for the production of precision machinery and fine chemical products With the development of science and technology, the production and processing of many industrial products place extremely high requirements on the dust concentration in the production environment, which requires a certain amount of Air cleanliness level and supply quality of various related substances required to control the production process. For example, in the production of film, if the film is contaminated with dust, emulsion oxidation, weakened activity, pH change, etc. will occur, which affects the photosensitive performance of the film.
   4. Cleanroom requirements for semiconductor and integrated circuit production
   Purification of semiconductor materials is an important basis for the development of semiconductor devices. Due to the process requirements of large-scale and ultra-large-scale integrated circuits, in order to obtain high-purity silicon materials, the high purity of raw materials and intermediate media and the cleanliness of the production environment have become a prominent issue affecting product quality.
   The yield of integrated circuit chips is related to the defect density of the chip, and the defect density of the chip is related to the number of particles in the air. Therefore, the rapid development of integrated circuits not only has extremely high requirements for controlling the size of particles in the air, but also needs to further control the number of particles; at the same time, there are also relevant requirements for the control of chemical pollution in the production environment of very large-scale integrated circuits.
   5. Cleanroom requirements for cosmetics and food production
   Most modern cosmetics contain protein, vitamins, amino acids, plant extracts, etc. These components provide favorable conditions for the growth and reproduction of microorganisms such as bacteria and mold. Therefore, microbial contamination is an important factor affecting the quality of cosmetics. The control objects of the clean room used in the production process of cosmetics are mainly dust particles and microorganisms, which are similar to the requirements of the clean room for the production of pharmaceuticals. At present, the cleanliness level of clean rooms for cosmetics production can be referred to the GMP regulations of pharmaceuticals.
  In the production process of the food factory, strict management of the facility is an important means to ensure the safety and hygiene of food, to prevent food poisoning caused by pathogenic coliforms and salmonella, or to mix mold in beverages. From the 1990s to the present, WHO and some developed countries introduced the HACCP (Hazard Analysis Key Control Point) system and formulated a food production recognition system that utilizes sanitation to manage the production process.
  Clean rooms are inseparable from the electronics, pharmaceutical, bioengineering, medical and health, food, cosmetics and military industries, providing a controlled environment that meets production needs and directly affects the quality of products. However, because the cleanliness requirements of cleanrooms in various industries are inconsistent, the relevant standards should be followed when designing cleanrooms to ensure that the clean environment meets the required standards.